Manipal Hospital Endocrinologist Highlights Hidden Diabetes Risk in Lean Indians: The Role of Genetics and Diet

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Hidden Diabetes in Lean Indians: Understanding the Overlooked Risk

Diabetes is a chronic metabolic disease characterized by high blood glucose levels due to the body’s inability to produce or effectively use insulin, as defined by the World Health Organisation (WHO). While often associated with obesity, recent studies reveal a troubling trend: lean individuals in India are increasingly being diagnosed with diabetes. This phenomenon has sparked concern among healthcare professionals, who point to both genetic predispositions and dietary habits as key factors.

Thin-Fat Indians: A New Medical Concern

Dr. Tejaswi V., a consultant in diabetes and endocrinology at Manipal Hospital, introduces us to the term “thin-fat Indians,” a concept coined by the renowned endocrinologist Dr. CN Yajnik. This term refers to individuals who are of normal body weight yet possess a significant amount of visceral fat—fat that accumulates around internal organs. This specific body composition poses serious health risks, leading to conditions like insulin resistance, which can quickly spiral into diabetes.

The Genetic Component

There’s a compelling argument that genetic makeup plays a critical role in the diabetes epidemic amongst lean individuals. Dr. Tejaswi notes that Indian genetics render populations more susceptible to insulin resistance, even at lower body weights. This susceptibility is exacerbated by certain genetic variants linked to the accumulation of visceral fat rather than subcutaneous fat, leading to health issues despite appearing lean on the surface. The notion that body weight alone is an insufficient marker of metabolic health is a paradigm shift that needs urgent attention.

The Thrifty Phenotype Hypothesis

Delving deeper, the Thrifty Phenotype Hypothesis provides a fascinating backdrop to understanding the heightened prevalence of diabetes. According to Dr. Tejaswi, this hypothesis explains how individuals who faced undernutrition early in life can develop issues when later exposed to abundant calorie-rich environments. This is particularly relevant in India, where many populations have experienced cycles of malnutrition followed by a sudden influx of processed, high-sugar foods.

Dietary Shifts and Sedentary Lifestyles

Modern dietary habits are undergoing a drastic transformation. Dr. Tejaswi highlights that the move towards refined grains, sugar-sweetened beverages, and processed foods leads to rapid spikes in blood sugar levels. Such nutritional shifts, combined with increasingly sedentary lifestyles, accelerate the onset of insulin resistance, particularly in those with a genetic predisposition. This connection prompts the question: Are we underestimating our risk factors by merely focusing on weight?

Rethinking Risk Assessment

A primary takeaway from Dr. Tejaswi’s insights is the urgent need to reconsider how we assess metabolic risk. Relying solely on Body Mass Index (BMI) as an indicator often under-represents the health dangers posed by individuals who may appear lean yet harbor significant amounts of visceral fat. It’s essential to recognize that weight is just one of many factors to consider when evaluating overall metabolic health.

Steps Toward Better Health

To combat the hidden threat of diabetes in lean individuals, Dr. Tejaswi advocates for a proactive approach that emphasizes awareness and lifestyle modifications. Understanding how genetics intertwine with dietary choices can empower individuals to make informed decisions about their health. Key recommendations include:

  1. Regular Screening: Regular health check-ups can facilitate early detection, allowing for timely intervention before diabetes progresses.

  2. Balanced Nutrition: Prioritizing whole grains, reducing sugar intake, and avoiding processed foods can positively influence metabolic health.

  3. Physical Activity: Engaging in regular physical activity is crucial for maintaining insulin sensitivity and overall health.

Taking these steps could make a significant difference in preventing the onset of diabetes and its associated long-term complications, particularly for those classified as “thin-fat.”


Note to readers: This article is for informational purposes only and not a substitute for professional medical advice. Always consult a medical professional with any questions regarding health conditions.

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